The FDA is warning that certain supplements contain toxic yellow oleander.
The plant is native to Mexico and contains cardiac glycosides (CGs). CGs are a class of naturally occurring steroid-like compounds, and members of this class have been in clinical use for more than 1500 years. They have been used in folk medicine as arrow poisons, abortifacients, heart tonics, emetics, and diuretics as well as in other applications. The major use of CGs today is based on their ability to inhibit the membrane-bound Na+/K+-ATPase enzyme, and they are regarded as an effective treatment for congestive heart failure (CHF), cardiac arrhythmia and atrial fibrillation. Furthermore, increasing evidence has indicated the potential cytotoxic effects of CGs against various types of cancer.
For more information and a list of products containing yellow oleander, visit FDA Issues Warning About Certain Supplements Substituted with Toxic Yellow Oleander | FDA.


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